Abstract WDR11, a gene associated with Kallmann syndrome, is important in reproductive system development but molecular understanding of its action remains incomplete.We previously reported that Wdr11-deficient embryos exhibit defective ciliogenesis and developmental defects associated with Hedgehog (HH) signalling.Here we demonstrate that WDR11 is
Metastatic breast cancer is a very heterogeneous disease, both from a clinical and a biological point of view.Despite being still incurable, the expanding therapeutic repertoire has determined a progressive increase in median survival.We describe the clinical course of a 67-year-old woman with a locally advanced, hormone-receptor positive breast ca
Abstract Background Histiocytic sarcoma (HS) is a rare neoplasm showing morphological and immunophenotypic features of mature tissue histiocytes.We report a patient with nodal HS exhibiting prominent reactive eosinophilic infiltration.Case presentation A 68-year-old man presented with intermittent left lower abdominal pain and weight loss over 3 mo